IF and only IF you are running Windows 10 Creator update (1703) or higher
It seems like it is now possible to run M-PC in hi DPI without issues (none found so far in my test)
To do that,
1- Set you PC display to its native resolution, example 3840x2160
2- Set the DPI to the recommended setting, like 150%, 250% etc...
3- Reboot (very important)
4-In the Start Menu, browse to Martin M-Series and right-click, the More, then Open File Location
5- An Explorer window should open showing shortcut to M-PC and Library Editor, for both you need to right-click and then Properties, then go to the Compatibility tab.
Check the Override High DPI scaling... and select SYSTEM in the drop list. (Do not select System Enhanced)
Do the same for Fixture Editor and M-Series Manager
Let me know if this works for you or not.
Still have to test in multi-monitor / multi-resolution scenario.